The Role of SnoN and Ski in Mammary Epithelial Cell Transformation

reportActive / Technical Report | Accession Number: ADA482792 | Open PDF

Abstract:

Ski and SnoN are members of Ski oncoprotein family. Overexpression of Ski or SnoN can induce transformation of chicken embryonic fibroblast. SkiSnoN is recently identified as a repressor of TGF signaling pathway which is an important tumor suppression pathway at the early stage of tumorigenesis. Higher level of SkiSnoN is found in transformed mammary epithelial cells. SkiSnoN might play a role in regulation of the transformation of mammary epithelial cell by antagonizing TGF signaling pathway. In my project, I try to explore the role of SkiSnoN in the transformation of mammary epithelial cells.

Author(s):
Pan, Deng
Author Organization(s):
CALIFORNIA UNIV BERKELEY
Descriptive Note:
Annual summary rept. 1 Jul 2004-1 Dec 2007
Supplementary Note:
The original document contains color images. DOI: 10.21236/ADA482792
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-04-1-0388
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_1.3.2_Personnel Management; JCA_5_Command and Control
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CELLS(BIOLOGY), *BREAST CANCER, *EPITHELIUM, *FIBROBLASTS, TRANSFORMATIONS, MAMMARY GLANDS, SKIS, SUPPRESSION, CHICKENS, NEOPLASMS, PRODUCTION, EMBRYOS
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
SNON, SENESCENCE, *MAMMARY EPITHELIAL CELLS
Report Date:
2007 Dec 01
Creation Date:
2008 Jul 09