Evaluation of Fibroblast Activation Protein-Alpha (FAP) as a Diagnostic Marker and Therapeutic Target in Prostate Cancer

reportActive / Technical Report | Accession Number: ADA482238 | Open PDF

Abstract:

Our goal is to evaluate FAP expression patterns and enzymatic activity in both normal prostate tissue and at various stages of oncogenic transformation i.e. PIA, PIN, Localized and Advanced Cancer to determine tumor stage in which FAP expression may play a role. A second objective is to exploit this expression in the treatment of prostate cancer by developing therapies targeted for activation by FAP. This will be accomplished by identifying selective peptide substrates for the proteolytic activity of FAP and coupling these peptides to a highly cytotoxic agent, thapsigargin, to generate prodrugs that are only activated in prostate tumors where FAP is expressed.

Author(s):
Brennen, Nathaniel
Author Organization(s):
JOHNS HOPKINS UNIV BALTIMORE MD
Descriptive Note:
Annual rept. 14 Mar 2006-28 Jun 2007
Supplementary Note:
DOI: 10.21236/ADA482238
Pagination:
0021

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
W81XWH-07-1-0059
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1.3.2_Personnel Management; JCA_1.2.3_Educating; JCA_1.2.5_Lessons Learned
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*PROSTATE CANCER, ENZYMES, PROTEINS, DIAGNOSIS(MEDICINE), FIBROBLASTS, PROSTATE GLAND, PEPTIDE HYDROLASES, TISSUES(BIOLOGY), THERAPY
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research
Keyword(s):
FAP(FIBROBLAST ACTIVATION PROTEIN ALPHA)
Report Date:
2007 Dec 01
Creation Date:
2008 Jun 18