Identification of Novel Inverted Terminal Repeat (ITR) Deletions of Human Adenovirus (AD) From Infected Host: Virulent Ads Containing Mixed Populations of Genomic Sequences

reportActive / Technical Report | Accession Number: ADA481581 | Open PDF

Abstract:

There are a total six different species of human Adenoviruses, designated A through F. All Ads implicated in US military ARD infections are confined within two Ad species, B and E. It was demonstrated and confirmed that the clinical human Ad isolates from natural infections examined in this study carrying random terminal ITR deletions. Whereas, laboratory adapted human Ads including Ad human vaccine strains, such as Wyeth Ad4 and Ad7 strains contain mostly homogeneous and intact ITR sequences. The finding of novel ITR deletions in clinical Ads of natural infections could have significant impacts on the future Ad research and vaccine development.

Author(s):
Houng, Huo-shu H. ; Binn, Leonard ; Kuschner, Robert ; Russell, Kevin ; Metzgar, David ; Lynch, Julia
Author Organization(s):
WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD DEPT OF VIRUS DISEASES
Descriptive Note:
Conference paper
Supplementary Note:
See also ADM002075., The original document contains color images. Presented at the Army Science Conference (25th) held in Orlando, FL on 27-30 November 2006.
Pagination:
0006

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
NHRC
 Subject Terms
Joint Capability Areas:
JCA_3.2_Engagement; JCA_3_Force Application; JCA_6.4.1_Secure Information Exchange; JCA_3.2.2_Non-Kinetic Means; JCA_6.4_Information Assurance; JCA_6_Net Centric; JCA_1_Force Support; JCA_8_Building Partnerships; JCA_1.4_Force Support; JCA_1.3_Human Capital Management; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_1.3.2_Personnel Management; JCA_1.4.1_Force Health Protection
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ADENOVIRUSES, CLINICAL MEDICINE, STRAINS(BIOLOGY), GENETIC MAPPING, VACCINES, HUMANS, INFECTIOUS DISEASES
Field(s)/Group(s):
Medicine and Medical Research, Microbiology
Keyword(s):
ARD(ACUTE RESPIRATORY DISEASE), ITR(INVERTED TERMINAL REPEAT)
Report Date:
2006 Nov 01
Creation Date:
2008 Jun 11