An Experimental System to Evaluate LOH in Prostate Cancer

reportActive / Technical Report | Accession Number: ADA477389 | Open PDF

Abstract:

The goal of this grant is to establish a new biological system for studying the progression of prostate cancer. We propose a technology we have previously developed to help define X-chromosome inactivation to increase our understanding of the molecular biology of prostate cancer. Using a mouse model, our goal is to induce functional Loss of Heterozygosity LOH on a particular chromosome at various specified time during development or life span. Specifically, we plan to induce LOH only in mouse prostatic tissue.

Author(s):
Strauss, William M.
Author Organization(s):
COLORADO UNIV AT BOULDER
Descriptive Note:
Final rept. 1 Jan 1999-30 Jun 2004
Pagination:
0012

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-99-1-9032
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CHROMOSOMES, *HETEROGENEITY, *MOLECULAR BIOLOGY, *PROSTATE CANCER, TISSUES(BIOLOGY), LOSSES, MICE, LIFE SPAN(BIOLOGY), ANATOMICAL MODELS, GROWTH(PHYSIOLOGY), PROSTATE GLAND
Field(s)/Group(s):
Genetic Engineering and Molecular Biology, Medicine and Medical Research
Keyword(s):
LOH(LOSS OF HETEROZYGOSITY), *LOSS OF HETEROZYGOSITY
Report Date:
2004 Jul 01
Creation Date:
2008 Mar 12