Optimization of Broad-Spectrum Antimicrobial Activity for Novel Compound Classes

reportActive / Technical Report | Accession Number: ADA471417 | Open PDF

Abstract:

This final report summarized the results obtained from the preparation, evaluation, and extensive SAR analysis of hundreds of compounds with an emphasis on improving the antimicrobial activity of three compound classes outlined in our original proposal. the first class include the substituted pyranosyl cytosines, the second class of compounds are the heterobiaryl guanidines, ant the third are bis-heteroarylamidrazones

Author(s):
Griffey, Richard H.
Author Organization(s):
ISIS PHARMACEUTICALS CARLSBAD CA
Descriptive Note:
Final rept. 25 Mar 2002-24 Mar 2005
Supplementary Note:
DOI: 10.21236/ADA471417
Pagination:
0110

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-02-2-0023
Monitor Series:
USAMRMC
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*MOLECULES, *BACTERIA, *RIBONUCLEIC ACIDS, *ANTIMICROBIAL AGENTS, *RECOGNITION, OPTIMIZATION, SPECTRA, GUANIDINES, BROADBAND
Field(s)/Group(s):
Biochemistry, Microbiology
Keyword(s):
SMALL MOLECULE, BIS HETEROARYLAMIDRAZONES, SRP(SIGNAL RECOGNITION PARTICLE)
Report Date:
2005 Apr 01
Creation Date:
2007 Sep 12