Angiogenesis and Invasiveness in Prostate Cancer Detected with High Spectral and Spatial Resolution MRi

reportActive / Technical Report | Accession Number: ADA470635 | Open PDF

Abstract:

We propose to develop new MR methods to improve early and accurate detection of prostate cancer, and guide treatment of the cancer. Although conventional MRI has high sensitivity, its specificity has been disappointing. New more specific and sensitive MRI methods would have a significant impact on clinical management of prostate cancer. Previous work in this laboratory showed that high spectral and spatial resolution HiSS MRI improves image quality and detection of the effects of contrast agents. HiSS images can be acquired with clinically acceptable run times by using frequency resolved echo planar methods to obtain detailed spectra of the water and fat resonances associated with each image voxel. We will test the hypothesis that Contrast enhanced HiSS MRI increases sensitivity to angiogenesis and invasiveness of prostate cancer. As a result HiSS MRI can accurately distinguish metastatic from non-metastatic cancer based on detailed scans of the primary tumor.

Author(s):
Karczmar, Greg
Author Organization(s):
CHICAGO UNIV IL
Descriptive Note:
Final rept. 24 Dec 2001-23 Jun 2006
Supplementary Note:
The original document contains color images.
Pagination:
0071

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-02-1-0033
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_1.2.3_Educating; JCA_5.3_Planning; JCA_4.6.1_General Engineering; JCA_4.6_Engineering; JCA_1.2.7_Experimentation; JCA_1.2.1_Training; JCA_1.2.5_Lessons Learned
Modernization Areas:
Fully Networked C3; Quantum Science and Computing
Communities of Interest:
Ground and Sea Platforms
Descriptor(s):
*MAGNETIC RESONANCE IMAGING, *PROSTATE CANCER, *ANGIOGENESIS, DETECTION, WATER, CLINICAL MEDICINE, NEOPLASMS, ACCURACY, SENSITIVITY, HIGH RESOLUTION, SPECTRA, ECHOES, PLANAR STRUCTURES, HYPOTHESES, FATS, COMPUTER AIDED DIAGNOSIS
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research
Keyword(s):
*HIGH SPECTRAL AND SPATIAL RESOLUTION, HISS(HIGH SPECTRAL AND SPATIAL RESOLUTION)
Report Date:
2006 Jul 01
Creation Date:
2007 Aug 22