Analytical Method and Detection Limit Studies for Detection of GB in GB Hydrolysate

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Abstract:

The work presented here describes the applicability of an extractionGCMS anaiyticai method for detection of GB in caustic matrices. The method was designed to minimize GB reformation and spiked GB degradation during workup and analysis. Extractions were performed at pH 9 and 4 deg. C, using methylene chloride as the solvent. The extraction ratio was 15 mL matrix to 1.5 mL solvent. The GCMSD in the SIM mode was used for analysis. The method was tested using two distinctly different sources of GB, one containing only TBA as stabilizer, and the other containing TBA and DICDI as stabilizers. Method detection limits MDL obtained for NaOH hydrolysate matrices produced from these sources were 4.5 ngmL ppb and 8.4 ngmL, respectively. The GB spike recoveries were 82.4 and 75.2, respectively. No GB reformation was observed in the TBA-stabilized unspiked hydrolysate. The GB was detected, presumably via reformation during analysis, in the TBADICDI-stabilized unspiked hydrolysate, but was below the MDL.

Author(s):
Rohrbaugh, Dennis K. ; Hondrogiannis, George ; Yang, Yu-chu
Author Organization(s):
EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD RESEARCH AND TECHNOLOGY DIR
Descriptive Note:
Final rept. Apr 2003-Apr 2005
Supplementary Note:
The original document contains color images.
Pagination:
0024

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
ECBC-TR-509
Monitor Series:
AMSCM-RDE
 Subject Terms
Joint Capability Areas:
JCA_7_Protection; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_8_Building Partnerships; JCA_5_Command and Control; JCA_8.2_Shape; JCA_5.3_Planning; JCA_8.2.2_Provide Aid to Foreign Partners and Institutions; JCA_7.1.2_Prevent Non-kinetic Attack; JCA_7.1_Prevent; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means; JCA_6_Net Centric; JCA_6.4.1_Secure Information Exchange
Communities of Interest:
Counter WMD
Descriptor(s):
*DETECTION, *GB AGENT, *TRACE ELEMENTS, NUCLEAR MAGNETIC RESONANCE, NEUTRALIZATION, MASS SPECTROMETRY, EXTRACTION, CHEMICAL ORDNANCE, HYDROLYSIS, GAS CHROMATOGRAPHY
Field(s)/Group(s):
Physical Chemistry, Chemical, Biological and Radiological Warfare, Atomic and Molecular Physics and Spectroscopy
Keyword(s):
METHOD DETECTION LIMIT, SELECTED ION MONITORING, STABILIZERS, GB REFORMATION, GB HYDROLYSATE, GB(ISOPROPYL METHYLPHOSPHONOFLUORIDATE), CHEMICAL WEAPONS, SARIN
Report Date:
2006 Jun 01
Creation Date:
2006 Nov 08