Design and Performance of GMR Sensors for the Detection of Magnetic Microbeads in Biosensors

reportActive / Technical Report | Accession Number: ADA453798 | Open PDF

Abstract:

We are developing a biosensor system, the Bead ARray Counter BARC, based on the capture and detection of micron-sized, paramagnetic beads on a chip containing an array of giant magnetoresistive GMR sensors. Here we describe the design and performance of our current chip with 64 sensor zones, compare its performance with the previous chip design, and discuss a simple analytical model of the sensor micromagnetics. With assay-ready Dynal M-280 microbeads 2.8 m diameter, our threshold for detection is approximately 10 beads per 200 m-diameter sensor. Single beads made of solid Ni30Fe70 can easily be detected, but they must be made biocompatible. The relatively large size of our sensors helps to improve their practical sensitivity compared with other microsensor-based magnetic particle detectors.

Author(s):
Rife, J. C. ; Miller, M. M. ; Sheehan, P. E. ; Tamanaha, C. R. ; Tondra, M. ; Whitman, L. J.
Author Organization(s):
NAVAL RESEARCH LAB WASHINGTON DC
Descriptive Note:
Journal article
Supplementary Note:
Published in Sensors and Actuators A, v107 p209-218, 2003. Sponsored in part by the Defense Advanced Projects Agency (DARPA).
Pagination:
0035

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
NRL
 Subject Terms
Joint Capability Areas:
JCA_1_Force Support; JCA_1.2_Force Preparation; JCA_1.2.3_Educating; JCA_8_Building Partnerships; JCA_5_Command and Control; JCA_5.3_Planning; JCA_6_Net Centric; JCA_8.2_Shape
Modernization Areas:
Quantum Science and Computing
Communities of Interest:
Sensors
Descriptor(s):
*MAGNETORESISTANCE, *PARAMAGNETISM, MATHEMATICAL MODELS, DETECTORS, PERFORMANCE(ENGINEERING), BEADS, MAGNETIC DETECTION, CHIPS(ELECTRONICS), MAGNETIC DETECTORS
Field(s)/Group(s):
Electricity and Magnetism
Keyword(s):
*BIOSENSORS, *MAGNETIC MICROBEADS, *MAGNETORESISTIVE SENSORS, *GMR(GIANT MAGNETORESISTIVE), BARC(THE BEAD ARRAY COUNTER), PARAMAGNETIC BEADS, MAGNETIC PARTICLE DETECTORS
Report Date:
2003 Mar 19
Creation Date:
2006 Sep 27