Green Tea in Prevention and Therapy of Prostate Cancer

Green tea consumption has been associated with a decrease in the risk of some cancer types in humans. Epidemiological studies, though inconclusive, suggest that drinking green tea may lower the risk of prostate cancer Cap in humans. Here we report that polyphenolic mixture obtained from green tea 0.1 GTP wv in drinking water at a human achievable dose equivalent to six cups of green tea per day significantly inhibits prostate cancer development and blocks metastases in transgenic adenocarcinoma of the mouse prostate TRAMP mice. The cumulative incidence of palpable tumors at 32 weeks of age in water-fed TRAMP was 100. However, GTP provided in drinking water to TRAMP mice from 8 to 32 weeks of age resulted in a significant delay in primary tumor incidence, b significant decrease in prostate and genitourinary weight, c significant inhibition in serum IGF-I and restoration of IGFBP-3 levels, d marked reduction in the protein expression of PCNA, and e increased apoptosis in the prostate compared to water-fed TRAMP mice. The striking observation of this study was that GTP infusion resulted in almost complete inhibition of distant site metastases. Furthermore, GTP consumption to TRAMP mice resulted in increased tumor free survival and prolonged life span of these mice.