Update: Vaccine Side Effects, Adverse Reactions, Contraindications, and Precautions Recommendations to the Advisory Committee on Immunization Practices (ACIP)

This report provides updated information concerning the potential adverse events associated with vaccination for hepatitis B, poliomyelitis, measles, mumps, diphtheria, tetanus, and pertussis. This information incorporates findings from a series of recent literature reviews, conducted by an expert committee at the Institute of Medicine lOM, of all evidence regarding the possible adverse consequences of vaccines administered to children. This report contains modifications to the previously published recommendations of the Advisory Committee on Immunization Practices ACIP and is based on an ACIP review of the lOM findings and new research on vaccine safety. In addition, this report incorporates information contained in the Recommendations of the Advisory Committee on Immunization Practices Use of Vaccines and Immune Globulins in Persons with Altered Immunocompetence MMWR 1993 42 No. RR-4 and the General Recommendations on Immunization Recommendations of the Advisory Committee on Immunization Practices ACIP MMWR l99443 No. RR-l . Major changes to the previous recommendations are highlighted within the text, and specific information concerning the following vaccines and the possible adverse events associated with their administration are included hepatitis B vaccine and anaphylaxis measles vaccine and a thrombocytopenia and b possible risk for death resulting from anaphylaxis or disseminated disease in immunocompromised persons diphtheria and tetanus toxoids and pertussis vaccine DTP and chronic encephalopathy and tetanus-toxoid-containing vaccines and a Guillain-Barre syndrome, b brachial neuritis, and c possible risk for death resulting from anaphylaxis. These modifications will be incorporated into more comprehensive ACIP recommendations for each vaccine when such statements are revised.