General Recommendations on Immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP), Morbidity and Mortaility Weekly Report, January 28, 1994. Volume 43, Number RR-1

Immunobiologic Immunobiologics include antigenic substances, such as vaccines and toxoids, or antibody-containing preparations, such as globulins and antitoxins, from human or animal donors. These products are used for active or passive immunization or therapy. The following are examples of immunobiologics a Vaccine A suspension of live usually attenuated or inactivated microorganisms e.g., bacteria, viruses, or rickettsiae or fractions thereof administered to induce immunity and prevent infectious disease or its sequelae. Some vaccines contain highly defined antigens e.g., the polysaccharide of Haemophilus influenzae type b or the surface antigen of hepatitis B others have antigens that are complex or incompletely defined e.g., killed BordeteIa pertussis or live attenuated viruses. For a list of licensed vaccines, see Table 1. b Toxoid A modified bacterial toxin that has been made nontoxic, but retains the ability to stimulate the formation of antitoxin. For a list of licensed toxoids, see Table 1. c Immune globulin IG A sterile solution containing antibodies from human blood. It is obtained by cold ethanol fractionation of large pools of blood plasma and contains 15-i 8 protein. Intended for intramuscular administration, IG is primarily indicated for routine maintenance of immunity of certain immunodeficient persons and for passive immunization against measles and hepatitis A. IG does not transmit hepatitis B virus, human immunodeficiency virus H IV, or other infectious diseases.