Enzyme Inhibitors of Cell-Surface Carbohydrates: Insects as Model Systems for Neuronal Development and Repair Mechanisms

reportActive / Technical Report | Accession Number: ADA382533 | Open PDF

Abstract:

An experimental drug, PDMP, has been shown to block metastasis by inhibiting the display of carbohydrates on tumor cell surfaces. Further work with PDMP and related drugs to prevent the spread of cancer now seems justified. This work is intended to show that rapidly growing insect nerve cells can serve as a model for cancer in humans, and simple assays based on this approach should permit the testing of a large number of new drugs based on PDMP. Drugs that block the outgrowth of the insect nerve cells should also block the outgrowth of cancer cells in humans, or other vertebrate organisms. Using this approach we should be able to rapidly develop potent new drugs which will block metastasis in human cancers.

Author(s):
Polt, Robin
Author Organization(s):
ARIZONA UNIV TUCSON
Descriptive Note:
Annual rept. 1 Jul 1999-30 Jun 2000
Supplementary Note:
DOI: 10.21236/ADA382533
Pagination:
0028

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-99-1-9539
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.3_Educating; JCA_5.3_Planning; JCA_1.2.7_Experimentation; JCA_1.2.5_Lessons Learned
Modernization Areas:
Directed Energy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*NEOPLASMS, *VERTEBRATES, *NERVE CELLS, *DRUGS, *CELLS(BIOLOGY), *CARBOHYDRATES, *CANCER, *METASTASIS, HUMANS, SURFACES, REPAIR, ASSAYING, POTENCY, INSECTS, ENZYME INHIBITORS
Field(s)/Group(s):
Anatomy and Physiology, Medicine and Medical Research
Keyword(s):
GLYCOSPHINGOLIPIDS, *TUMOR CELL
Report Date:
2000 Jul 01
Creation Date:
2000 Oct 18