Perchlorate Literature Review and Summary: Developmental Effects, Metabolism, Receptor Kinetics and Pharmacological Uses.

Perchlorate is a monovalent anion found as a soil and groundwater contaminate on government contractor sites and, more recently, on an Air Force site. Perchlorate is dissociated from the salt, ammonium perchlorate, which is an efficient oxidizer used in solid rocket propellant systems. This review was undertaken to evaluate the available information on developmental and reproductive effects, thyroid iodide receptor kinetics, pharmacological uses of perchlorate outside the treatment of Graves disease, and absorption, distribution, metabolism and excretion of perchlorate. Summarization of the available information and conclusions make the data more accessible to toxicologists and review panels for consideration in study prioritization and future reference dose development.