The Effects of the Infusion of Stroma-Free Hemoglobin Into Dogs with Spleens

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Abstract:

Stroma-free hemoglobin SFH solutions may be useful as a resuscitative fluid having oxygen-transporting capacity. SFH modified by intramolecular and intermolecular crosslinking has been shown to have longer vascular retention times. Potential problems with the infusion of SFH include vasoconstrictor effects, renal toxicity, increased methemoglobin levels, and disseminated intravascular coagulation.

Author(s):
Valeri, C. R. ; Pivacek, Linda E. ; Cassidy, George ; Gray, Alan
Author Organization(s):
NAVAL BLOOD RESEARCH LAB BOSTON MA
Descriptive Note:
Technical rept.
Pagination:
0070

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
NBRL BUSM-91-09
Contract/Grant Number(s):
N00014-88-C-0118
Monitor Series:
ONR
 Subject Terms
Joint Capability Areas:
JCA_1_Force Support; JCA_1.3_Human Capital Management; JCA_1.3.2_Personnel Management; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1.2.7_Experimentation
Communities of Interest:
Biomedical
Descriptor(s):
*FLUIDS, *HEMOGLOBIN, *DOGS, *SPLEEN, *RESUSCITATION, *INFUSIONS, PROPAGATION, TOXICITY, OXYGEN, CROSSLINKING(CHEMISTRY), RETENTION(GENERAL), ERYTHROCYTES, CARDIOVASCULAR SYSTEM, METHEMOGLOBIN, KIDNEYS, BLOOD COAGULATION
Field(s)/Group(s):
Biochemistry, Anatomy and Physiology, Medicine and Medical Research
Keyword(s):
*SFH(STROMA FREE HEMOGLOBIN), VASCULAR RETENTION, VASOCONSTRICTOR EFFECTS, BIS 3, 5 DIBROMOSALICYL FUMARATE, BOVINE, GLUTARALDEHYDE, HEMODYNAMICS, *STROMA FREE HEMOGLOBIN
Report Date:
1991 Jun 03
Creation Date:
1999 Mar 10