Preclinical Toxicology Studies for New Drugs and Vaccines.

reportActive / Technical Report | Accession Number: ADA343280 | Open PDF

Abstract:

This project evaluated the toxicity and safety of several drugs under development. During the contract, tasks conducted included mutagenicity tests developmental toxicity studies in rats and rabbits acute toxicity studies in rats and mice two, four and thirteen week toxicity studies in rats and dogs a six month toxicity study in rats fertilitylearly embryonic development studies, in rats a perinatal toxicity study in rats and a one year toxicity study in dogs. Drugs studied included WR242S ii Tartrate, WR2386OS Succinate, Halofantrine HCl, Pyridostigmine Bromide, WR6O26 Dihydrochioride, H1-6 Dichloride, WR26941O, Atropine, WR279396, and Ampicillin.

Author(s):
Levine, Barry D.
Author Organization(s):
ILLINOIS UNIV AT CHICAGO CIRCLE
Descriptive Note:
Final rept. 15 Nov 91-15 Apr 98,
Supplementary Note:
DOI: 10.21236/ADA343280
Pagination:
0033

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-92-C-2001
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_1.2.5_Lessons Learned; JCA_5.3_Planning; JCA_5.3.3_Develop Strategy; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action
Communities of Interest:
Biomedical
Descriptor(s):
*CLINICAL MEDICINE, *CASE STUDIES, *VACCINES, *TOXICOLOGY, RATS, MICE, PYRIDOSTIGMINE BROMIDE, DOGS, PENICILLINS, ATROPINE, LABORATORY ANIMALS
Field(s)/Group(s):
Medicine and Medical Research, Pharmacology
Report Date:
1998 May 01
Creation Date:
1998 May 20