Breast Mucin Tumor-Specific Epitopes for Cancer Immunotherapy

reportActive / Technical Report | Accession Number: ADA339039 | Open PDF

Abstract:

The objectives of the research program are to study the structure-immunogenicity relationships of a hypoglycosylated human tumor-specific mucin common to breast and other adenocarcinomas. Hypo-glycosylation of breast mucin leads to exposure of a tumor-specific epitope TSE. The structural and immunogenic properties of the TSE are being examined using synthetic mucin peptides and recombinant mucin proteins that contain the TSE andor mutations in potential glycosylation sites surrounding the TSE.

Author(s):
Dombrowski, Kenneth E.
Author Organization(s):
TEXAS TECH UNIV AMARILLO
Descriptive Note:
Annual rept. 1 Aug 96-31 Jul 97
Pagination:
0019

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-94-J-4161
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_1.2.5_Lessons Learned; JCA_5.3_Planning
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*IMMUNIZATION, *MUCIN, *BREAST CANCER, STRUCTURAL PROPERTIES, PEPTIDES, PROTEINS, NEOPLASMS, MUTATIONS, RESPONSE, THERAPY, ANTIBODIES, MONOCLONAL ANTIBODIES, CELLS(BIOLOGY), CARBOHYDRATES, ANTIGENS, VACCINES, SUGARS, MAMMARY GLANDS, IMMUNOGENS
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research, Pharmacology
Keyword(s):
ANATOMICAL SAMPLES, TUMOR SPECIFIC EPITOPE, IMMUNOTHERAPY, IMMUNOGENICITY, GLYCOSYLATION
Report Date:
1997 Oct 01
Creation Date:
1998 Apr 08