The RIZ Gene in Human Breast Cancer

reportActive / Technical Report | Accession Number: ADA338850 | Open PDF

Abstract:

The RIZ gene was isolated based on binding to the retinoblastoma tumor suppressor protein. RIZ gene normally produces two protein products, RIZ1 and RIZ2, that differ in length by the presence or absence of a conserved protein motif, the PR domain, found in a subfamily of Kruppel-like zinc finger genes. RIZ2 lacks the PR domain. RIZ gene maps to human chromosome band 1p36, a region that is commonly deleted or altered in a variety of human cancers including those of breast, neurocrest, colon, and liver tissues. RIZ1 and RIZ2 are widely expressed in normal tissues. However, RIZ1 was undetectable in 4 of 5 breast carcinoma specimens and in 4 of 10 breast cancer cell lines.

Author(s):
Huang, Shi
Author Organization(s):
BURNHAM INST LA JOLLA CA
Descriptive Note:
Annual rept. 1 Sep 96-31 Aug 97
Pagination:
0016

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-96-1-6209
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*GENES, *BREAST CANCER, TISSUES(BIOLOGY), HUMANS, PROTEINS, ISOLATION, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, LIVER, CELLS(BIOLOGY), AMINO ACIDS, SUPPRESSORS, NORMALITY, COLON
Field(s)/Group(s):
Biochemistry, Genetic Engineering and Molecular Biology, Medicine and Medical Research
Keyword(s):
TUMOR SUPPRESSORS, RIZ1 PROTEIN, RIZ GENE, RB(RETINOBLASTOMA GENES), TRANSCRIPTION FACTORS, KRUPPEL LIKE ZINC FINGER GENES
Report Date:
1997 Sep 01
Creation Date:
1998 Apr 01