Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Sets.

reportActive / Technical Report | Accession Number: ADA332661 | Open PDF

Abstract:

Vesication and skin irritation studies were conducted in hairless guinea-pigs to determine the vesicant and skin irritation potential of Chemical Agent Identification Sets CAIS. The CAIS training items that agent HD, HN, or L and were declared obsolete in 1971. Guinea-pigs were topically dosed with test article NEAT HD, 10 agentchloroform solutions, or product solutions wastestreams and evaluated for skin-damaging effects gross and light microscopic. Product solutions from the chemical neutralization of neat sulfur mustard resulted in microvesicle formation vesication. All agent-dosed agentchloroform solutions or HD sites exhibited microblisters, as well as other histopathologic lesions of the skin. Wastestreams from the neutalization of agent agentchloroform agent on charcoal were devoid of microvesicant activity. Dermal irritant effects erythema and edema were consistent with the skin-injurious activity associated with the neutralizing reagent 1,3-DICHLORO-5,5-DIMETHYLHYDANTOIN DCDMH.

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