Cellular Interactions in the Suprachiasmatic Nucleus.

During the period 1993-1997 of support from AFOSR, we completed many papers. Some of those listed below deal exclusively with the subject of the proposal, the suprachiasmatic nucleus, and some deal indirectly with issues related to the circadian clock or transmitters found in the SCN. A substantial effort was invested in examining the two primary transmitters in the SCN, glutamate, which is excitatory, and GABA, which is inhibitory. These two are particularly important because the primary input from the retina that phase-shifts the clock is glutamate, and the primary transmitter made by SCN cells themselves is GABA.