Structural Determination of the Factors Which Influence Molecular Adhesion to Polymer Surfaces.

The extent of interaction between a protein layer and a surface is influenced by three major factors the chemical architecture of the surface, its mobility, and its complexity. This project has provided the chance to prepare well characterized surfaces with controlled architecture which could be used to test various hypotheses of protein adhesion. The results of this comprehensive study will provide clear guidelines for the molecular design and the processing protocols required to produce minimally adhesive surfaces and those which provide optimum release under hydrodynamic shear.