The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer

reportActive / Technical Report | Accession Number: ADA322376 | Open PDF

Abstract:

Heparin-binding epidermal growth factor-like growth factor HB-EGF is a member of the EGF family which binds to and activates the EGF receptor. Its role in breast cancer, however, is unclear. We have studied the regulation of HB-EGF expression in nontransformed and transformed mammary epithelial cells. HB-EGF is induced by 12-0- tetradecanoylphorbol- 13-acetate TPA in most of the cell lines analyzed. In contrast with transforming growth factor alpha or amphiregulin, HB-EGF is not induced by estrogen or progesterone in any of the estrogen responsive, estrogen receptor positive breast cancer cell lines examined. HB-EGF RNA levels are induced by EG-related peptides in the spontaneously immortalized mammary epithelial cell line.

Author(s):
Salomon, David S.
Author Organization(s):
NATIONAL INSTITUTES OF HEALTH BETHESDA MD
Descriptive Note:
Annual rept. 30 Sep 95-29 Sep 96,
Pagination:
0051

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-94-J-4498
Monitor Series:
USAMRMC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.3_Educating; JCA_5.3_Planning; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_1.2.5_Lessons Learned; JCA_1.2.7_Experimentation
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*GROWTH(PHYSIOLOGY), *HEPARIN, *BREAST CANCER, RIBONUCLEIC ACIDS, MAMMARY GLANDS, PROGESTERONE, ANTICOAGULANTS, EPITHELIUM, PHOSPHORYLATION, CELLS(BIOLOGY), PEPTIDES, ESTROGENS
Field(s)/Group(s):
Biochemistry, Medicine and Medical Research, Pharmacology, Organic Chemistry
Keyword(s):
*HEPARIN BINDING EPIDERMAL GROWTH FACTOR, HB EGF(HEPARIN BINDING EPIDERMAL GROWTH FACTOR), EGF RECEPTOR, TPA(TETRADECANOYLPHORBOL 13 ACETATE), TETRADECANOYLPHORBOL 13 ACETATE, ALPHA TRANSFORMING GROWTH FACTOR, AMPHIREGULIN TRANSFORMING GROWTH FACTOR
Report Date:
1996 Oct 01
Creation Date:
1997 Apr 02