P53 Mutation Profiles in Premenopausal Versus Postmenopausal Breast Cancer in a Stationary Population.

One major clinical problem is how to predict which patients will relapse and metastasis. Recently, Dr. Yu has found that loss of the pl6 gene is directly associated with the loss of cancer cell adhesion, the first step for metastasis. We aim to test our hypothesis that 1 the inactivation of pl6 gene is higher in the metastatic cancers than non-metastatic cancers 2 the adhesion strength of pl6 cancer cells is higher than that of pl6 cancer cells 3 the incidence of metastasis in vivo is higher in pl6 cancer cells than pl6 cancer cells and 4 transfection of wildtype pl6 cDNA can reduce metastasis in vivo. This study will help us to elucidate whether the pl6 gene plays a role in the metastasis of cancers, and to screen and mark cancer metastasis potential, which will be beneficial in the early detection, prevention, and gene therapy of cancer metastasis.