A Pharmacological Profile of Glycopyrrolate: Interactions at the Muscarinic Acetylcholine Receptor

reportActive / Technical Report | Accession Number: ADA274877 | Open PDF

Abstract:

Glycopyrrolate, a synthetic quaternary ammonium compound had biphasic effects on the contraction of guinea-pig atrium. At concentrations between 0.4 and 20 microM, glycopyrrolate induced a small but consistent increase in the contraction force. Our results confirm the antimuscarinic properties of glycoprrolate. We suggest that the therapeutic value of glycopyrrolate in treatment of organophosphate poisoning is associated with its potency against prolonged muscarinic receptor activation by cholinergic agonists.

Author(s):
Lau, Wai-man ; Szilagyi, Maria
Author Organization(s):
DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION CANBERRA (AUSTRALIA)
Annotation:
Reprint: A Pharmacological Profile of Glycopyrrolate: Interactions at the Muscarinic Acetylcholine Receptor
Pagination:
0007

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
X5
 Subject Terms
Joint Capability Areas:
JCA_3_Force Application; JCA_1.4_Force Support; JCA_3.2_Engagement; JCA_3.2.1_Kinetic Means; JCA_1.4.1_Force Health Protection; JCA_1.2.7_Experimentation; JCA_3.1.3_Maneuver to Influence; JCA_3.1_Maneuver; JCA_1.3_Human Capital Management; JCA_1_Force Support; JCA_5.3_Planning; JCA_5_Command and Control; JCA_6_Net Centric
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*RECEPTOR SITES(PHYSIOLOGY), *PHARMACOLOGICAL ANTAGONISTS, *MUSCARINE, GLYCOPROTEINS, PATIENTS, DIAPHRAGMS(ANATOMY), CARDIAC GLYCOSIDES, BLOOD BRAIN BARRIER, PARASYMPATHOMIMETIC AGENTS, ATROPINE, CHOLINESTERASE INHIBITORS, NERVES
Field(s)/Group(s):
Biochemistry, Biology, Pharmacology
Report Date:
1992 Jan 01