Preclinical Toxicology Studies For New Drugs and Vaccines.

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Abstract:

The purpose of this study is to determine specific target organ toxicity, dose-response relationships, and a no adverse effect level of WR6026 in Beagle dogs following thirteen weeks of daily oral administration. In addition, the reversibility of these toxic effects over a 90-day recovery period will be assessed. Treatment was initiated on 5792. Necropsies were conducted on 86-792 and 115-692 after the three month treatment period and a three month recovery period, respectively.

Author(s):
Levine, Barry S.
Author Organization(s):
ILLINOIS UNIV AT CHICAGO CIRCLE DEPT OF PHARMACOLOGY
Descriptive Note:
Annual rept. 15 Nov 91-14 Nov 92,
Pagination:
0005

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-92-C-2001
Task Number(s):
BO
Project Number(s):
3M463807D808
Monitor Series:
USAMRDC
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*TOXICITY, *DRUGS, *VACCINES, *ORAL DOSAGE, TOXICOLOGY, TOXIC HAZARDS, ORGANS(ANATOMY), MUTAGENS
Field(s)/Group(s):
Toxicology, Pharmacology
Keyword(s):
PE63807A, AS808, WUDA335986, Necropsies, Skin protectants, Anticynide agent, HI 6 Dichloride
Report Date:
1992 Dec 07