Development of Methods for Detection of Lipid Peroxidation Products in Human Tissues Generated by Environmental Toxins.

reportActive / Technical Report | Accession Number: ADA254091 | Open PDF

Abstract:

Research to date has resulted in the synthesis of isotope labelled 9- oxononanoate and the development of generic methods for the introduction of a variety of isotopic labels in the 4-hydroxyalkenals. Additional studies demonstrated that 4-hydroxyalkenals could be released from protein sulfhydryl groups. Future studies will investigate whether 4-hyroxynonenal binds to the sulfhydral groups on human rhodopsin interfering with the visual transduction process.

Author(s):
Van Kuijk, Frederik J.
Author Organization(s):
MONTANA STATE UNIV BOZEMAN DEPT OF CHEMISTRY
Descriptive Note:
Annual rept. 1 Jul 91-30 Jun 92,
Supplementary Note:
DOI: 10.21236/ADA254091
Pagination:
0004

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFOSR-TR-92-0755
Contract/Grant Number(s):
AFOSR-90-0327
Task Number(s):
A5
Project Number(s):
2312
Monitor Series:
TR-92-0755, AFOSR
 Subject Terms
Joint Capability Areas:
JCA_1.2_Force Preparation; JCA_1_Force Support; JCA_1.2.3_Educating
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*PROTEINS, *EYE PIGMENTS, DETECTION, HUMANS, ISOTOPES, LABELS, SYNTHESIS, LIPIDS
Field(s)/Group(s):
Biology
Keyword(s):
*LIPID PEROXIDATION, HUMAN TISSUES, PROTEIN SULFHYDRAL GROUPS, PE61102F
Report Date:
1992 Jun 30