Human Immunodeficiency Virus (HIV) Infections: Strain and Type Variations; Diagnosis and Prevention

reportActive / Technical Report | Accession Number: ADA237815 | Open PDF

Abstract:

The results show that a the replicative capacity of HIV-2, like HIV-1, correlates with the severity of immunodeficiency b molecular clones of a rapidhigh HIV-1 isolate may have restricted replicative capacity compared to the genetically heterogenous isolate. Transfection of the same molecular clones into different cell types may yield progeny viruses with different phenotypes c monocyte tropism is a general property of HIV isolates. In some cases silent infection is established. Silently infected monocytemacrophages harbor virus that can be recovered by cocultivation with peripheral blood mononuclear cells.

Author(s):
Erling, Norrby ; Fenyo, Eva M.
Author Organization(s):
KAROLINSKA INST STOCKHOLM (SWEDEN)
Descriptive Note:
Midterm rept. 30 Sep 1989-31 Mar 1991,
Supplementary Note:
DOI: 10.21236/ADA237815
Pagination:
0019

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-89-Z-9038
Task Number(s):
AD
Project Number(s):
3M263105DH29
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_1.3.1_Personnel and Family Support; JCA_1.3.2_Personnel Management; JCA_1.2.5_Lessons Learned; JCA_5_Command and Control
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*MOLECULES, INFECTIOUS DISEASES, BLOOD CELLS, QUIET, NUCLEI, CLONES, HUMAN IMMUNODEFICIENCY VIRUSES
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
HIV, GENOMIC IMMUNOGENIC, SITE DIRECTED SEROLO, IMMUNE PROTECTION, ACQUIRED IMMUNE DEFICIENCY, ASH29, PE63105A, WUDA330785
Report Date:
1991 Apr 30