Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivo and as Directed by Cloned Cholinesterase DNA Sequences

reportActive / Technical Report | Accession Number: ADA235425 | Open PDF

Abstract:

Acetylcholinesterase ACHE is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase BCHE, it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis.

Author(s):
Soreq, Hermona
Author Organization(s):
HEBREW UNIV JERUSALEM (ISRAEL)
Descriptive Note:
Final rept. 25 Sep 1987-24 Sep 1990
Pagination:
0156

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-87-C-7169
Task Number(s):
AE
Project Number(s):
3MI61102BS12
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.7_Experimentation; JCA_1.2.5_Lessons Learned; JCA_1.2.3_Educating; JCA_1.2.6_Concepts; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_JCA_4.1.2_Sustain the Force; JCA_4.1_Deployment and Distribution; JCA_4.3_Maintain
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CONTROL, BIOLOGY, HUMANS, MOLECULES, HEALTH, ENZYMES, PROTEINS, TARGETS, DEOXYRIBONUCLEIC ACIDS, SEQUENCES, GENES, CLONES, MUSCLES, JUNCTIONS, IN VIVO ANALYSIS, SYNAPSE, AGRICULTURE, ACETYLCHOLINESTERASE, INSECTICIDES, POISONS, CHOLINESTERASE, NERVES, CHEMICAL WARFARE AGENTS, BIOSYNTHESIS, CHOLINERGIC NERVES, ACETYLCHOLINE
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
*ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, CDNA CLONING, XENOPUS OOCYTE EXPRESSION, GENE AMPLIFICATION, MUTAGENESIS, PE61102A, WU156, ASS12
Report Date:
1990 Oct 24