Mechanism of Action of Ribavirin on Bunyavirus Infected Cells

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Abstract:

Ribavirin 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide or Virazole is a broad-spectrum antiviral agent whose molecular mode of action remains remarkably controversial. The drug was approved by the Food and Drug Administration in 1986 for aerosol use in infants with serious infections due to respiratory syncytial virus RS Ribavirin is and has been under clinical investigation against a variety of viral illness, including those due to influenza virus, Lassa fever, Korean hemorrhagic fever with renal sydrome KHFS and human immunodeficiency virus HIV. There has been a great deal of clinical interest in utilizing ribavirn for HIV infections. It has been reported to slow the development of AIDS in HIV infected patients 1. We described here the major mechanisms of actions of this newly licensed drug. js

Author(s):
Patterson, Jean L.
Author Organization(s):
CHILDREN'S HOSPITAL CORP BOSTON MA
Descriptive Note:
Final rept.
Pagination:
0044

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release, Document Partially Illegible
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited. Document Partially Illegible.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-87-C-7004
Task Number(s):
AH
Project Number(s):
3M162787A871
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_1.2.7_Experimentation; JCA_1.3.2_Personnel Management
Communities of Interest:
Biomedical
Descriptor(s):
*AEROSOLS, CLINICAL MEDICINE, SPECTRA, ILLNESS, BROADBAND, KOREA, INFECTIOUS DISEASES, DRUGS, ANTIVIRAL AGENTS, HEMORRHAGIC FEVERS, VIRUSES, HUMAN IMMUNODEFICIENCY VIRUSES, FOOD, INFLUENZA VIRUS, INFANTS, ACUTE RESPIRATORY DISEASE VIRUS, GROUP B ARBOVIRUSES, MOLECULES
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
RIBAVIRIN, BUNYAVIRUS, ANTIVIRAL, MECHANISM OF ACTION, CELL CULTURES, PE62787A, AS871, WU397
Report Date:
1990 Oct 01