Analysis of Saxitoxin from Urine Using Dynamic FAB/MS

reportActive / Technical Report | Accession Number: ADA226474 | Open PDF

Abstract:

Analytical procedures for the analysis of saxitoxin STX have been investigated using Continuous Flow Fast Atom Bombardment CFFAB. Items investigated included derivative formation of STX resolution by micro capillary open tube columns 25 to 100 microns i.d., CFFAB matrices, solvent flow rates, probe tip design and selection of fragment ions for analysis by Selected Ion Recording. Five-hundred picograms of STX can be reproducibly detected by SIR using a matrix made up of 5 thioglycerol, 1 acetic acid and 0.05 sodium dodecyl sulfate. Keywords RA 1, BD, Lab animals, Guinea pigs, Rats, Saxitoxin, Dynamic FAB, Analysis, Mass spectrometer.

Author(s):
Mirocha, Chester J. ; Cheong, Won J. ; Abbas, Hamed
Author Organization(s):
MINNESOTA UNIV ST PAUL
Descriptive Note:
Rept. for 15 Jul 1989-14 Jul 1990
Supplementary Note:
DOI: 10.21236/ADA226474
Pagination:
0083

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-89-C-9101
Task Number(s):
AH
Project Number(s):
3M263002D807
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1.2.7_Experimentation; JCA_1.2.3_Educating; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_1.3.2_Personnel Management; JCA_4.3_Maintain
Modernization Areas:
Microelectronics
Communities of Interest:
Biomedical
Descriptor(s):
*TOXICITY, RATS, FLOW RATE, GUINEA PIGS, RECORDING SYSTEMS, MASS SPECTROMETERS, URINE, LABORATORY ANIMALS, IONS, SOLVENTS
Field(s)/Group(s):
Toxicology
Keyword(s):
WU052, PE63002A
Report Date:
1990 Jul 31