Synthesis of Ring Fluorinated Pyrazoles and Isoxazoles. The Effect of 2- Fluoro and 2-Chloro Substituents on the Keto-Enol Equilibria of 1,3-Diketones

reportActive / Technical Report | Accession Number: ADA223054 | Open PDF

Abstract:

To develop a synthesis of ring fluorinated heterocycles. A variety of pyrazoles and isoxazoles can now be prepared conveniently in one step, starting from their corresponding 2-fluoro-1,3-diketones, using ETOH as the solvent and an acid as the catalyst. The effect of fluorine and chlorine on the keto-enol equilibria of 1,3-diketones was also examined and rationalized on the basis of stereoelectronic effects. Fluoro-pyrazoles Fluoro-isoxazoles Organic compounds 2-fluoro-1,3-diketones Theses ETOH Keto-emolequilibria Ethyl alcohol.

Author(s):
Sloop, Joseph C.
Author Organization(s):
NORTH CAROLINA STATE UNIV AT RALEIGH DEPT OF CHEMISTRY
Descriptive Note:
Final rept. 25 May 1988-18 May 1990
Supplementary Note:
Master's thesis.
Pagination:
0040

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Subject Terms
Joint Capability Areas:
JCA_6.3.3_Spectrum Management; JCA_6.3_Net Management; JCA_6_Net Centric; JCA_1_Force Support; JCA_1.2_Force Preparation
Modernization Areas:
Fully Networked C3
Communities of Interest:
C4I
Descriptor(s):
*SYNTHESIS, *RINGS, *FLUORINATION, *PYRAZOLES, CATALYSTS, CHLORINE, ETHYL RADICALS, ALCOHOLS, ORGANIC COMPOUNDS, FLUORINE, THESES
Field(s)/Group(s):
Organic Chemistry
Keyword(s):
KETO ENOL EQUILIBRIA, ISOXAZOLES, ETOH, 1, 3 DIKETONES
Report Date:
1990 May 01