Assessment of the Developmental Toxicity of Propylene Glycol Monomethyl Ether Acetate (PM Acetate) in Rats

reportActive / Technical Report | Accession Number: ADA221988 | Open PDF

Abstract:

This study evaluated the potential maternal, embryotoxic and teratogenic parameters of propylene glycol monomethyl ether acetate in Sprague- Dawley rats following inhalation of vapors in days 6-15 of gestation. No teratological or other developmental effects were seen in fetuses at air concentrations as high as 4000 parts per million, in spite of slight toxic effects in dams at concentrations as low as 500 ppm. It is recommended that a an interim Workplace Exposure Limit be established at 100 ppm with a Short Term Exposure Limit of 150 ppm, b the beta isomer constitutes no more than 3 percent of the total PM Acetate in all military specifications, c an inhalation developmental study be performed in the rabbit, and d workers be monitored for the central nervous system and irritation effects. Teratology, Teratogenic, Rats, Inhalation, PM acetate, Propylene glycol monomethyl ether acetate, Propylene glycol methyl ether acetate, Biochemistry, Toxic hazards.

Author(s):
Asaki, Arthur E. ; Houpt, John T.
Author Organization(s):
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
Descriptive Note:
Final rept.
Pagination:
0028

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
USAEHA-75-51-0753-90
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_6.4.1_Secure Information Exchange
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*TOXICITY, *BIOCHEMISTRY, TOXIC HAZARDS, RATS, SPECIFICATIONS, VAPORS, IRRITATION, MILITARY REQUIREMENTS, LIMITATIONS, CENTRAL NERVOUS SYSTEM, RABBITS, EXPOSURE(GENERAL), INHALATION
Field(s)/Group(s):
Toxicology
Keyword(s):
PROPYLENE GLYCOL MONOMETHYL ETHER ACETATE (PM ACETATE)
Report Date:
1989 Dec 01