The Mechanism of Action of Ribavirin on Bunyavirus Infected Cells

reportActive / Technical Report | Accession Number: ADA218936 | Open PDF

Abstract:

Ribavirin 1-B-D-ribofuranosyl-1-1,2,4-triazole-3-carboxamide or Virazole is a broad-spectrum antiviral agent whose molecular mode of action remains remarkably controversial. The drug was approved by the Food and Drug Administration in 1986 for aerosol use in infants with serious infections due to respiratory syncytial virus RS. Ribavirin is and has been under clinical investigation against a variety of viral illness, including those due to influenza virus, Lassa fever, Korean hemorrhagic fever with renal syndrome KHFS and Human immunodeficiency virus HIV. There has been a great deal of clinical interest in utilizing ribavirin for HIV infections. It has been reported to slow the development of AIDS in HIV infected patients McCormick et al., 1984. We describe here the reported mechanisms of action of this newly licensed drug. jg

Author(s):
Patterson, Jean L.
Author Organization(s):
CHILDREN'S HOSPITAL CORP BOSTON MA
Descriptive Note:
Midterm rept. 1 Aug 1987-31 Jan 1989,
Pagination:
0013

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-87-C-7004
Task Number(s):
AH
Project Number(s):
3M162787A871
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_3.2_Engagement; JCA_3_Force Application; JCA_6_Net Centric; JCA_7.1.2_Prevent Non-kinetic Attack; JCA_7.1_Prevent; JCA_7_Protection; JCA_3.2.2_Non-Kinetic Means; JCA_6.4_Information Assurance; JCA_3.2.1_Kinetic Means; JCA_6.3.3_Spectrum Management; JCA_5_Command and Control; JCA_5.3_Planning; JCA_6.3_Net Management; JCA_1.4_Force Support; JCA_1.4.1_Force Health Protection; JCA_1_Force Support; JCA_8_Building Partnerships
Communities of Interest:
Biomedical
Descriptor(s):
*CELLS(BIOLOGY), *HUMAN IMMUNODEFICIENCY VIRUSES, *DRUGS, *INFECTIOUS DISEASES, *ANTIVIRAL AGENTS, ILLNESS, KOREA, HEMORRHAGIC FEVERS, VIRUSES, FOOD, CULTURES(BIOLOGY), INFLUENZA VIRUS, KIDNEYS, ACUTE RESPIRATORY DISEASE VIRUS, SPECTRA, CLINICAL MEDICINE, BIOCHEMISTRY, GROUP B ARBOVIRUSES, AEROSOLS, MOLECULES
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
PE62787A, WU397
Report Date:
1989 Mar 03