Interaction of Microcystin-LR with SuperChar: Water Decontamination and Therapy

reportActive / Technical Report | Accession Number: ADA218376 | Open PDF

Abstract:

Activated charcoal SuperChar has been recommended for therapeutic use against poisoning by several toxic agents, but it has not been tested against poisoning by several toxic agents, but it has not been tested against microcystin-LR toxicosis. Microcystin-LR, a cyclic heptapeptide isolated from fresh water blue-green algae, has been shown to be a potent hepatotoxin in animals and in man. Studies were performed to determine the degree of in vitro adsorption of microcystin-LR to SuperChar and to assess the efficacy of SuperChar as a therapeutic agent against microcystin-LR in vivo. Scatchard analysis of the in vitro data showed that microcystin-LR bound to SuperChar with a maximum binding capacity of 0.692 mM toxing SuperChar with a dissociation constant of 0.016mM. The adsorption characteristics of microcystin-LR by SuperChar was applied successfully to the decontamination of water samples spiked with SuperChar 0.31-0.36 gkg modulated the toxicity, an oral pretreatment with SuperChar did not prevent lethality induced by an oral or intraperitoneal ip dose of microcystin-LR in mice. Reprints.

Author(s):
Mereish, Kay A. ; Solow, Rikki
Author Organization(s):
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Supplementary Note:
Availability: Pub. in Jnl. of Clinical Toxicology v27 n4-5 p271- 280, 1989. No copies furnished by DTIC/NTIS.
Annotation:
Reprint: Interaction of Microcystin-LR with SuperChar: Water Decontamination and Therapy.
Pagination:
0012

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
USAMRID
 Subject Terms
Joint Capability Areas:
JCA_1.4_Force Support; JCA_1.4.2_Health Service Delivery; JCA_5.3_Planning; JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_1_Force Support
Communities of Interest:
Biomedical
Descriptor(s):
*POISONING, *WATER, *TOXIC AGENTS, ADSORPTION, TOXICITY, IN VITRO ANALYSIS, FRESH WATER, ACTIVATED CARBON, SAMPLING, THERAPY, ANIMALS, LETHALITY, MICE, LIVER, BLUE(COLOR), GREEN(COLOR), POTENCY, TOXINS AND ANTITOXINS, ORAL INTAKE, CAPACITY(QUANTITY), ALGAE, REPRINTS, DECONTAMINATION
Field(s)/Group(s):
Toxicology
Report Date:
1988 Jan 01