Acute Oral Toxicity of JA-2 Solid Propellant in ICR Mice

The acute oral toxicity of JA-2 Solid Propellant was determined in male and female ICR mice by using an oral gavage, split-dose method. The MLD was 3774.6 or - 150.5 mgkg for male mice and 3528.8 or - 133.8 mgkg for female mice. JA-2 produced component, diethyleneglycol dinitrate and nitroglycerin. These signs included tremors, inactivity, depression of reflexes, loss of equilibrium, opisthotonus, and increased respiratory activity. Other clinical signs observed were associated with the general malaise of the animals following dosing and included perianal staining, hunched posture, squinting, and rough coat. Most animals exhibited signs by 2 hours after dosing and either had died or the signs had cleared within 5 days of dosing. According to the classification scheme of Hodge and Sterner, these results place JA-2 in the slightly toxic class. Keywords Acute oral toxicity JA-2 solid propellant Diethyleneglycol dinitrate Nitroglycerin Mammalian toxicology Propellant Mice.