A Cepstral Analysis of EEG (Electroencephalographic) Signals in Motion Sickness Studies

This research studied electroencephalographic EEG signals during the evolution of motion sickness. It used cepstral transformation techniques and hypothesis testing to investigate the relationships between phenytoin serum levels and malaise period EEG signals. It used the same techniques to study the relationships between phenytoin-malaise period EEG signals and placebo-malaise period EEG signals. It also studied the relationships between pre-malaise period EEG signals for phenytoin and placebo trials. Eighteen male subjects were given the drug phenytoin in a double-blind, placebo-controlled crossover experiment. Subjects were rotated in a motion chair while eight physiological parameters were measured. Although the drug delayed or prevented the onset of emesis, no statistically significant relationships were found between phenytoin serum levels and frontal-midline EEG signals. Keywords Military Theses Motion Sickness. KT