Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs

reportActive / Technical Report | Accession Number: ADA215151 | Open PDF

Abstract:

The Department of Defense is considering the use of diethyleneglycol dinitrate DEGDN as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords Mammalian toxicology, Buehler test, Munition.

Author(s):
Letellier, Yvonne C. ; Brown, Larry D. ; Korte, Jr, Don W.
Author Organization(s):
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Descriptive Note:
Rept. for 4 Apr-6 May 1986
Pagination:
0044

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
LAIR-411, TOXICOLOGY SER-179
Task Number(s):
AB
Project Number(s):
3E162720A835
Monitor Series:
USABRDL
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_6_Net Centric; JCA_6.3.3_Spectrum Management; JCA_5.3.3_Develop Strategy; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action; JCA_6.3_Net Management; JCA_6.4.1_Secure Information Exchange; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_1.2.5_Lessons Learned; JCA_1_Force Support; JCA_3.2_Engagement; JCA_3_Force Application; JCA_5.2_Understand; JCA_6.1_Information Transport; JCA_6.4_Information Assurance; JCA_3.2.1_Kinetic Means
Communities of Interest:
Biomedical
Descriptor(s):
*SKIN(ANATOMY), *ETHYLENE GLYCOL, *NITRATES, *SOLID PROPELLANTS, *TOXICITY, MALES, NITROGLYCERIN, TOXICOLOGY, FORMULATIONS(CHEMISTRY), TEST AND EVALUATION, GUINEA PIGS, MAMMALS, DEPARTMENT OF DEFENSE, SENSITIVITY
Field(s)/Group(s):
Toxicology, Ammunition and Explosives
Keyword(s):
BUEHLER TEST, MAMMALIAN TOXICOLOGY, PE62720A, WUDA303913
Report Date:
1989 Oct 01