Temperature Regulation Following Systemic Anticholinergic or Anticholinesterase Therapy

reportActive / Technical Report | Accession Number: ADA212155 | Open PDF

Abstract:

The effect of systemic atropine ATR, 2 mg, im or pyridostigmine PYR, 30 mg, oral at rest and during moderate seated cycle exercise was evaluated in two separate protocols at an ambient temperature of 30 C. Esophageal Tes and mean weighted skin temperatures were measured continuously, as was forearm sweating rate, forearm blood flow FBF, venous occlusion plethesmography and cutaneous perfusion SkBF, laser doppler velociometry. Whole body sweating decreased 55 P0.05 in ATR, while heart rate increased 30 bpm P0.05. ATR increased the slope central thermosensitivity of FBF Tes 90 P0.05 compared to control. The Tes for sweating onset was increased 0.3 C P0.05 after ATR.

Author(s):
Kolka, Margaret A. ; Stephenson, Lou A.
Author Organization(s):
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
Pagination:
0007

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
USARIEM-M58-89
Task Number(s):
BC
Project Number(s):
3M463751D993
Monitor Series:
USARIEM
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.2_Exercising; JCA_1.2.7_Experimentation
Communities of Interest:
Ground and Sea Platforms
Descriptor(s):
*TEMPERATURE CONTROL, *CHOLINESTERASE INHIBITORS, *ATROPINE, *EXERCISE(PHYSIOLOGY), *HEAT STRESS(PHYSIOLOGY), RATES, LASERS, CYCLES, WEIGHTING FUNCTIONS, DOPPLER SYSTEMS, HEART RATE, ARMS(ANATOMY), PLETHYSMOGRAPHY, SWEAT COOLING, ESOPHAGUS, BODY TEMPERATURE, CARBAMATES, PERFUSION, BLOOD CIRCULATION, SKIN(ANATOMY), VELOCIMETERS, MEAN, LASER APPLICATIONS, ANTIDOTES, THERAPY
Field(s)/Group(s):
Stress Physiology, Pharmacology
Keyword(s):
*PYRIDOSTIGMINE, ANTICHOLINERGIC DRUGS, VENOUS OCCLUSION PLETHESMOGRAPHY, CUTANEOUS PERFUSION, LASER DOPPLER VELOCIOMETRY, THERMOSENSITIVITY, WU183, PE63751A
Report Date:
1989 May 01