Receptor Binding and Membrane Transport of Botulinum Toxins.

reportActive / Technical Report | Accession Number: ADA198935 | Open PDF

Abstract:

The goal of this research is to characterize the interaction of botulinum neurotoxin with membranes, and seeks to add to the field of study of proteinlipid interactions in general. A model system of study has been developed to define which portions of the botulinum toxin insert andor interact with artificial liposomes in order to define membrane-active portions of the molecule. This will enable a more defined study of the protein as it interacts with a bilayer through the use of protein and membrane probes to map the topography of the toxin in the membrane, and will also define possibly critical areas of the molecule which can be used as templates to produce artificial inhibitors of botulinum activity. AW

Author(s):
Dankert, John R.
Author Organization(s):
FLORIDA UNIV GAINESVILLE
Descriptive Note:
Annual rept. 1 Apr 87-31 Mar 88,
Pagination:
0023

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-86-C-6062
Task Number(s):
AA
Project Number(s):
3M162770A871
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation; JCA_1_Force Support; JCA_1.2.5_Lessons Learned; JCA_1.2_Force Preparation; JCA_1.3_Human Capital Management; JCA_3.2_Engagement; JCA_3_Force Application; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support
Communities of Interest:
Biomedical
Descriptor(s):
*MEMBRANES(BIOLOGY), *TRANSPORT PROPERTIES, *CYTOPLASM, *BACTERIAL TOXINS, *CLOSTRIDIUM BOTULINUM, PROBES, MODELS, INTERACTIONS, LIPIDS, PROTEINS, TOPOGRAPHY, TEMPLATES, INHIBITORS, TOXINS AND ANTITOXINS
Field(s)/Group(s):
Biochemistry, Toxicology, Pharmacology
Keyword(s):
PE62770A, AS871, WU386
Report Date:
1988 Mar 01