The Influence of Acetyl Salicylic Acid (Aspirin) and Acetaminophen on Clinical and Histologic Aspects of Orthodontic Tooth Movement

Of particular interest, currently in orthodontic literature, is the effect that prostaglandins have on the rate and quantity of tooth movement. High local concentrations of prostaglandins can result in an increased rate and quantity of tooth movement while prostaglandin inhibitors can have the opposite effect. Utilizing 42 Hartley guinea pigs, two experimental groups and one control group were established to examine the influence of therapeutic doses of aspirin and acetaminophen, both prostaglandin synthesis inhibitors, on clinical and histologic aspects of orthodontic tooth movement. Clinical and histologic results revealed no statistical differences among the controls and either of the experimental groups. Given the influence that prostaglandins have on tooth movement, it seems reasonable to recommend against the use of prostaglandin inhibitors for the relief of orthodontic discomfort. However, this study did not produce evidence to contraindicate the use of prostaglandin inhibitors, by orthodontic patients, on the possibility that tooth movement will be significantly slowed down by consumption of the drugs. Theses.