Calculated Melting Temperature of Methylated Z-DNA.

There are two approaches to theoretical calculation of DNA melting temperature. One is based on a two states, quasi-one-dimensional lattice model in which the melting profile and differentiated melting curve could be calculated as a function of DNA length. Another way is the modified self-consistent effective phonon approximation MSPA in which the dynamic motional behavior of the DNA molecule during the melting process is detailed. We use the later approach to melting of methylated Z-DNA in this paper and compare our results to a similar calculation on unmethylated B-DNA. In this paper we present a calculation of melting temperature of methylated Z-DNA Deoxyribonucleic acid based on MSPA.