Regulation of the Immune System by Hypothalamic Releasing Hormones.

reportActive / Technical Report | Accession Number: ADA187395 | Open PDF

Abstract:

It has been known for many years that stressful situations can be a contributing factor in the development of a variety of bacterial, viral and neoplastic diseases. Specifically, decreased immuno-competence seems to account for the increased susceptibility of stressed hosts for these disease states. We have suggested that one mechanism by which this can occur is through the action of neuroendocrine hormones. It appears that the immune and neuroendocrine systems communicate in a bidirectional regulatory circuit by virtue of common signal molecules and receptors. In this report we discuss our findings on the amino acid sequence and post translational processing of lymphocyte derived corticotropin ACTH. Also, presented are results that hte hypothalamic releasing hormones for luteinizing hormone LH and thyrotropin TSH induce lymphocytes to synthesize immunoreactive LH and TSH, respectively. Finally, we discuss our data that the ACTH recepto on lymphocytes acts through adenylate cyclase like the prototype on adrenal tissue. Keywords Hypothalamic releasing hormones, Stress, Immune system, ACTH, Endorphins, Corticosteroids, Monokines, Neuroimmunomodulation, StressPhysiology.

Author(s):
Smith, Eric M.
Author Organization(s):
TEXAS UNIV MEDICAL BRANCH AT GALVESTON
Descriptive Note:
Annual rept. Jul 86-Sep 87,
Pagination:
0023

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
N00014-84-K-0486
Task Number(s):
RR04108441
Project Number(s):
RR04108
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_5.3.1_Analyze Problem; JCA_1.2.3_Educating; JCA_1.2.7_Experimentation; JCA_1.2.5_Lessons Learned
Modernization Areas:
Directed Energy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*HORMONES, *HYPOTHALAMUS, *NEUROCHEMISTRY, ADENYL CYCLASE, ADRENOCORTICOTROPIC HORMONE, AMINO ACIDS, CORTICOSTEROID AGENTS, DISEASES, ENDOCRINE GLANDS, IMMUNITY, LYMPHOCYTES, MOLECULES, NEOPLASMS, NEUROLOGY, PITUITARY HORMONES, RELEASE, SEQUENCES, SIGNALS, SYNTHESIS, THYROTROPIN, IMMUNOSUPPRESSION, STRESS(PSYCHOLOGY), EMOTIONS, PATHOPHYSIOLOGY
Field(s)/Group(s):
Medicine and Medical Research, Biochemistry, Anatomy and Physiology, Psychology
Keyword(s):
*Hypothalamic releasing hormones, Luteinizing hormone, Thyrotropin, Endorphins, Corticosteroids, Monokines, PE61153N, WUF004
Report Date:
1987 Nov 01