Subchronic Toxicity Study on 1,4-Dithiane.

This 90-day investigation was undertaken to determine the subchronic toxicologic and pathologic effects, if any, of 1,4-dithiane in the rat. Several doses three doses per sec as well as a control were used in order to obtain as much information as possible at non-toxic dose levels. In a preliminary 14-day range-finding study, rats were gavaged daily at 0,25, 50, 100, 210 and 420 mgkgday 6 ratssexdose. No overt toxicity or mortality was observed. The female livers and the make kidneys were significantly heavier in the treated animals. There was deposition of anisotropic crystals of an undetermined chemical composition in the nasal olfactory mucosa of both sexes of the high and intermediate dose groups. The livers of the high dose females contained two hepatocellular lesions minimal hypertrophy in the centrilobular region and minimal cytoplasmic vacuolation in the periportal region.