Genotoxicity of Dyes Present in Colored Smoke Munitions.

reportActive / Technical Report | Accession Number: ADA181755 | Open PDF

Abstract:

The Lovelace Inhalation Toxicology Research Institute has been coduction genetic toxicology studies on organic dyes used in colored smoke munitions. This report summarizes the results of tests to determine the genotoxic potency of the dyes toward both bacteria and mammalian cells in vitro. The tests were conducted to detect mutations in bacteria and mammalian cells and to determine cell killing, alterations in cell cycle kinetics, sister chromatid exchanges, and chromosome aberration induction in mammalian cells. The dyes evaluated in the report include Solvent Red 24, Solvent Red 1, Disperse Red 11 and terephthalic acid. Disperse Red 11 had chemical contamination that seemed to be responsible for some mutagenic activity. Keywords Disperse Red 11, Solvent Red 24, Solvent Red 1, Genotoxicity, Dyes, Disperse Red 15.

Author(s):
Henderson, Rogene F. ; Brooks, Antone L. ; Hanson, Ray L.
Author Organization(s):
LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST
Descriptive Note:
Final rept. 1 Nov 84-1 Jun 86,
Pagination:
0125

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_5.3_Planning; JCA_5.2_Understand; JCA_1.2.5_Lessons Learned
Modernization Areas:
Fully Networked C3
Communities of Interest:
Biomedical
Descriptor(s):
*DYES, *CELLS(BIOLOGY), *COLORED SMOKES, *SMOKE MUNITIONS, *TOXICITY, BACTERIA, CHEMICAL CONTAMINATION, CHROMOSOMES, DISTORTION, INHALATION, IN VITRO ANALYSIS, MAMMALS, MUTATIONS, CYCLES, KINETICS, CHROMATIN, GENETICS, TOXICOLOGY, MUTAGENS, ORGANIC COMPOUNDS, SOLVENT DYES, POTENCY, TIN
Field(s)/Group(s):
Toxicology, Ammunition and Explosives
Report Date:
1986 Jul 07