Therapeutic Approaches to the Treatment of Botulism

reportActive / Technical Report | Accession Number: ADA181603 | Open PDF

Abstract:

In vitro experiments have been done on isolated phrenic nerve- hemidiaphragm preparations. The purpose of the experiments was to evaluate aminopyridines as putative therapeutic agents in the treatment of botulism and to develop monoclonal antibodies that would neutralize botulinum toxin and tetanus toxin. The work demonstrates that aminopyridines are active against type A botulinum toxin. Research on antibodies is still in progress. Keywords Antidotes Botulism Food poisoning.

Author(s):
Simpson, Lance L.
Author Organization(s):
JEFFERSON MEDICAL COLL PHILADELPHIA PADEPT OF MEDICINE
Descriptive Note:
Annual rept. 1 Sep 1985-31 Jul 1986
Supplementary Note:
DOI: 10.21236/ADA181603
Pagination:
0014

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-85-C-5285
Task Number(s):
AD
Project Number(s):
3M161102BS12
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_3_Force Application; JCA_3.2_Engagement; JCA_3.2.1_Kinetic Means; JCA_1.2.7_Experimentation; JCA_3.1.3_Maneuver to Influence; JCA_3.1_Maneuver; JCA_5_Command and Control; JCA_1.4_Force Support; JCA_4.6.2_Combat Engineering; JCA_4.6_Engineering; JCA_5.3_Planning; JCA_6.1_Information Transport; JCA_6_Net Centric; JCA_1.2_Force Preparation; JCA_1_Force Support
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CHEMOTHERAPEUTIC AGENTS, *BOTULISM, IN VITRO ANALYSIS, ANTIDOTES, ANTIBODIES, CLONES, TOXINS AND ANTITOXINS, BACTERIAL TOXINS, CLOSTRIDIUM BOTULINUM, FOOD POISONING, TETANUS
Field(s)/Group(s):
Pharmacology
Keyword(s):
*AMINOPYRIDINES, MONOCLONAL ANTIBODIE, PE61102A, WU118, ASS12
Report Date:
1986 Oct 01