Mechanisms of Cellular Membrane Effects of TCDD (2,3,7,8-Tetrachlorodibenzo-p-Dioxin) Selected Perfluorinated Acids and Polyhalogenated Aromatic Hydrocarbons.

reportActive / Technical Report | Accession Number: ADA177372 | Open PDF

Abstract:

Two model systems were used to examine the phenomenon of metabolic cooperation between cells. The recovery of ARL-TG superscript r cells in the presence of hepatocytes and 6-thioguanine was examined. Perfluorodecanoic acid and 2, 2 4, 4 5, 5 hexachlorobiphenyl have significant effects on metabolic cooperation between cells implying that these chemical interfere with gap junction function and hence interrupt cell-cell communication. These results were confirmed in autoradiographic studies in which the transfer of Tritium uridine between donor and recipient cells was examined. If these compounds inhibit cell-cell communication in vivo, then that may be one mechanism by which the toxic effect is exerted. Keywords Polychlorinated biphenyls.

Author(s):
Rogers-beck,
Author Organization(s):
MICROBIOLOGICAL ASSOCIATES INC BETHESDA MD
Descriptive Note:
Final technical rept. 1 Aug 84-31 Jul 86,
Pagination:
0038

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFOSR-TR-87-0201
Contract/Grant Number(s):
F49620-84-C-0074
Task Number(s):
A5
Project Number(s):
2312
Monitor Series:
TR-87-0201
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation; JCA_1.3.2_Personnel Management; JCA_1.2.5_Lessons Learned
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*MEMBRANES(BIOLOGY), *TOXICITY, *LIVER, *HALOGENATED HYDROCARBONS, MODELS, RATS, METABOLISM, HYDROCARBONS, AROMATIC HYDROCARBONS, TRANSFER, MICE, CELLS(BIOLOGY), COOPERATION, FLUORINATED HYDROCARBONS, FLUORINATION, CARBOXYLIC ACIDS, CHLORINATED HYDROCARBONS, ACIDS, CHLORINE COMPOUNDS, AUTORADIOGRAPHY, TRITIUM, DIOXINS, BIPHENYL, URIDINE
Field(s)/Group(s):
Toxicology
Keyword(s):
Dioxin 2, 3, 7, 8 Tetrachlorodibenzo P, PE61102F, WUAFOSR2312A5
Report Date:
1986 Oct 15