Cyanide Prophylaxis and Cytochrome Oxidase.

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Abstract:

The research is on the treatment and prophylaxis of cyanide intoxication. 1. The toxicology and pathology of sodium nitrite and sodium thiosulfate were examined by the intramuscular route. 2. Studies are concerned with evaluation of DMAP and sodium nitrite as cyanide antagonists on a prophylactic and therapeutic conditions. 3. The effect of cyanide on cytochrome oxidase under in vitro conditions were studied with various cyanide antagonists. 4. A new class of cyanide antagonists are being developed. 5. Various reviews on cyanide antagonism are shown.

Author(s):
Way, James L.
Author Organization(s):
TEXAS A AND M RESEARCH FOUNDATION COLLEGE STATION
Descriptive Note:
Annual rept. 1 May 83-30 Apr 85,
Pagination:
0178

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAMD17-83-C-3140
Task Number(s):
EF
Project Number(s):
3M161102BS11
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ANTIDOTES, *CYANIDES, *CHEMOTHERAPY, *INTOXICATION, *CYTOCHROME OXIDASE, IN VITRO ANALYSIS, PATHOLOGY, PREVENTIVE MEDICINE, PHARMACOLOGICAL ANTAGONISTS, TOXICOLOGY, CHEMOTHERAPEUTIC AGENTS, SODIUM COMPOUNDS, SODIUM NITRITE, THIOSULFATES
Field(s)/Group(s):
Toxicology, Pharmacology
Keyword(s):
DMAP(Dimethylaminophenol), Phenol Dimethylamino, PE61102A, ASS11, WU023
Report Date:
1985 Sep 15