HMX: Acute Toxicity Tests in Laboratory Animals.

reportActive / Technical Report | Accession Number: ADA171598 | Open PDF

Abstract:

The US Army requires information on the acute toxicity potential of Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine HMX by oral, dermal and intravenous jroutes. In addition data on the acute skin and eye irritancy and skin sensitisation potentials of HMX are required. This report gives details of the following tests performed on HMX to meet these requirements. Acute Oral Toxicity LD50 Test in Rats. Acute Oral Toxicity LD50 Test in Mice. Acute Oral Toxicity in Rabbits Dose Ranging. Acute Dermal Toxicity LD50 in Rats. Acute Dermal Toxicity LD50 in Rabbits. Intravenous Toxicity LD50 in Rats. Intravenous Toxicity in Rabbits Dose Ranging. Primary Skin Irritation Test in Rabbits. Eye Irritation HMX 60 ww in distilled water in Rabbits. Eye Irritation dried HMX in Rabbits. Allergenic Potential in Guinea Pigs Magnusson-Kligman Maximisation Test.

Author(s):
Cuthbert, J. A. ; D'arcy-burt, K. J. ; Carr, S. M.
Author Organization(s):
INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (SCOTLAND)
Descriptive Note:
Final rept. Jun 80-Jan 81,
Pagination:
0204

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
IRI-2051
Contract/Grant Number(s):
DAMD17-80-C-0053
Task Number(s):
00
Project Number(s):
3E162720A835
 Subject Terms
Joint Capability Areas:
JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_3.2_Engagement; JCA_3_Force Application; JCA_1.2_Force Preparation; JCA_1_Force Support; JCA_3.2.1_Kinetic Means; JCA_6.3.3_Spectrum Management; JCA_6_Net Centric; JCA_4.3_Maintain
Modernization Areas:
Fully Networked C3
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*TOXICOLOGY, *HMX, RATS, TOXICITY, TEST METHODS, EXPLOSIVES, DOSAGE, EYE, MICE, SKIN(ANATOMY), ORAL DOSAGE, RABBITS, GUINEA PIGS, CONVULSIVE DISORDERS, ALLERGENS, IRRITATION
Field(s)/Group(s):
Toxicology, Ammunition and Explosives
Keyword(s):
Acute toxicity, PE6272OA, AS835, WU104
Report Date:
1985 Jul 30