Study of African Trypanosomiasis.

Muriithi, I.; Reardon, M. J.; Wellde, B. T.; Hockmeyer, W. T.; Roberts, L. W.

Study of African Trypanosomiasis.

Active / Technical Report | Accession Number: ADA154092 |

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Abstract:

The pathogenesis of Trypanosoma brucei rhodesiense was studied in 42 cattle experimentally infected with different isolates from Kenya, Ethiopia and Tanzania. Nineteen of the cattle died or were terminated in extremis 3-60 months post inoculation. Nine of 11 isolates tested produced central nervous system CNS disorder in the cattle. The CNS disorders developed early 3 months in some animals and later 60 months in others. Parasites were difficult to find on wet blood smears or by subinoculations of blood after the fourther month of infection. Parasites persisted in lymph nodes, however. It appears that the bovine is a suitable model for T.b. rhodesiense infection with syndromes similar to those in human infections. Berenil R treatment of hosts and subsequent transmission of T. congolense and T. vivax by tsetse flies were investigated. The complement fixation CF test and the micro-ELISA were compared in the diagnosis of visceral leishmaniasis, Originator-supplied keywords include Glossina morsitans, kala-azar, Leishmania donovani, and Complement fixation test.

Author(s):

Muriithi, I. ; Reardon, M. J. ; Wellde, B. T. ; Hockmeyer, W. T. ; Roberts, L. W.

Author Organization(s):

ARMY MEDICAL RESEARCH UNIT-KENYA APO NEW YORK 09675

Descriptive Note:

Annual rept. 1 Oct 79-30 Sep 80,

Pagination:

0028

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Identifying Numbers

Contract/Grant Number(s):

DAMD17-79G-9461

Task Number(s):

00

Project Number(s):

3M162770A802

Subject Terms

Joint Capability Areas:

JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_1.3_Human Capital Management; JCA_1_Force Support; JCA_6.1_Information Transport; JCA_6_Net Centric; JCA_8_Building Partnerships; JCA_1.3.1_Personnel and Family Support; JCA_5_Command and Control; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate

Communities of Interest:

Biomedical

Descriptor(s):

*PATHOGENESIS, *EPIDEMIOLOGY, *TRYPANOSOMIASIS, SIGNS AND SYMPTOMS, DIAGNOSIS(GENERAL), INOCULATION, BOVINES, CENTRAL NERVOUS SYSTEM, LEISHMANIA, LEISHMANIASIS, BLOOD, ORGANS(ANATOMY), KENYA, LYMPH NODES, ETHIOPIA

Field(s)/Group(s):

Animal Husbandry and Veterinary Medicine

Keyword(s):

Glossina Morsitans, Kala azar, Leishmania donovani, Trypanosoma brucei rhodesiense, PE62770A, AS802, WU067

Report Date:

1980 Sep 30