An Atropinized Heat-Stressed Rat Model: Dose Response Effects and Pharmacokinetics,

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Abstract:

Atropine and other anticholinergic drugs are widely used in common medications such as antihistamines and tranquilizers as well as in the treatment of organophosphate poisoning. Since atropine administration inhibits thermoregulatory efficiency in the heat in both man and the rat by reducing sweating and salivation respectively, we sought to quantitate the effects of atropine in our rat heatstroke model. Using this sedentary, heat-stressed rat model, we have determined that atropine increases the heating rate up to 3h after drug administration and that this elevation in heating rate is dose-dependent over the range from 10-1000ugkg. The clinically used human dosages of atropine fall well within this range.

Author(s):
Matthew, C. B. ; Hubbard, R. W. ; Francesconi, R. P.
Author Organization(s):
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
Pagination:
0024

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
USARIEM-M3/85
Project Number(s):
3M162734A875
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ATROPINE, *HEAT STRESS(PHYSIOLOGY), RATES, HEATING, PHYSIOLOGICAL EFFECTS, DOSAGE, TEMPERATURE CONTROL, PHARMACOKINETICS, ANATOMICAL MODELS, HEAT STROKE
Field(s)/Group(s):
Stress Physiology, Pharmacology
Keyword(s):
*Anticholinergic drugs, PE62734A, WU042, AS875
Report Date:
1984 Oct 01