Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Rats.

White, C. W.; Rodriguez, J.; Marrs, G. E., Jr

Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Rats.

Active / Technical Report | Accession Number: ADA137309 |

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Abstract:

The acute toxicities of a single oral dose of the DMSO process stream samples, DMSO Evaporator Sludge, DMSO Recycle Solvent, and Virgin DMSO, were determined in male and female albino Sprague-Dawley rats. The DMSO Evaporator Sludge and Virgin DMSO solutions produced no deaths in male or female rats at a limit dose level of 5.0 m1kg. The DMSO Recycle Solvent was more toxic, and a LD50 with 95 percent confidence limit was calculated by probit analysis. The DMSO Recycle Solvent LD50 was 2.1 m1kg in male rats, 95 percent confidence limit 1.5 m1kg, 2.8 m1kg, and 1.3 m1kg in female rats, 95 percent confidence limit 1.0 m1kg, 1.8 m1kg.

Author(s):

White, C. W. ; Rodriguez, J. ; Marrs, G. E., Jr

Author Organization(s):

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Descriptive Note:

Final rept. 29 Dec 82-5 Apr 83,

Pagination:

0046

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Identifying Numbers

Report Number(s):

LAIR-164

Subject Terms

Joint Capability Areas:

JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_5.3_Planning; JCA_6.4.1_Secure Information Exchange; JCA_1.2.5_Lessons Learned; JCA_6_Net Centric; JCA_6.4_Information Assurance; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means; JCA_5.2_Understand; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_1_Force Support; JCA_5.5_Direct; JCA_5.5.1_Communicate Intent and Guidance; JCA_1.3_Human Capital Management; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support

Modernization Areas:

Autonomy

Communities of Interest:

Biomedical

Descriptor(s):

*TOXICITY, *METHYL SULFOXIDE, ORAL DOSAGE, MORTALITY RATE, PATHOLOGY, LEVEL(QUANTITY), RATS

Field(s)/Group(s):

Toxicology

Keyword(s):

DSMO(Dimethyl Sulfoxide), Dimethyl sulfoxide

Report Date:

1983 Nov 01